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| Wednesday 5/1 Insider Buying Report: CLF, HWBK
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| Wednesday's ETF with Unusual Volume: MARB
Wed, 01 May 16:39:55 GMT |
   
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HiFi Long-Read Sequencing Panel Supports Comprehensive Analysis of 20 Genes Associated With Neurological Disease
"HiFi sequencing is uniquely capable of comprehensively characterizing the germline and somatic variation of tandem repeats1 which cause dozens of neurological diseases.2 Our new PureTarget repeat expansion panel is designed to target these repeat expansions to help our customers understand the underpinnings of tandem repeats," said Christian Henry, President and Chief Executive Officer of PacBio. "This product uses a differentiated method to do targeted long-read sequencing of DNA in its pure state. PureTarget libraries retain methylation signatures, which saves our customers from having to run a separate assay while providing a complete picture for disease genes like FMR1. With a simplified workflow and fast turnaround time, we believe this panel could bring PacBio an increased commercial opportunity in the form of tens of thousands of samples in the world's largest laboratories." Targeted sequencing is an ideal method for researchers and commercial laboratories looking to cost-effectively study and analyze the role of specific genes and gene variants. The 20 genes that comprise the PureTarget repeat expansion panel are implicated in a wide range of debilitating neurological diseases that afflict children and adults including ataxia, Huntington's disease, myotonic dystrophy, amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Fragile-X disease. "This new kit has opened up really exciting opportunities for our research program focused on repeat expansions and inherited eye disease," said Alice Davidson, Associate Professor at University College London. "The relatively lower DNA input requirements, coupled with high read depth output, has allowed us to uncover levels of repeat mosaicism and instability at our repeat locus of interest with affected cell populations." Continuing the commitment to deliver comprehensive solutions, PacBio has prioritized delivering end-to-end workflows with their latest products. The PureTarget Repeat Expansion Panel workflow utilizes the recently announced Nanobind PanDNA kit, ensuring robust results optimized for Revio and Sequel IIe users. Customers can multiplex up to 48 samples on the PacBio Revio sequencing system and 24 samples on the PacBio Sequel IIe sequencing system. Additionally, PacBio provides intuitive data analysis for genotyping through a new workflow driven by Tandem Repeat Genotyping Tools (TRGT), as recently featured in Nature Biotechnology. The new PureTarget panel is expected to be available for shipment starting March 25, 2024. More information about PacBio application kits is available here. About PacBio PacBio products are provided for Research Use Only. Not for use in diagnostic procedures. Forward-Looking Statements Contacts Investors: Media:
SOURCE Pacific Biosciences of California, Inc. 
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